162 Dominant role of IL-4 over IL-13 in inhibiting IL-23 secretion by human dendritic cells

Interleukin (IL)-4 and IL-13 are related cytokines that share a common signaling pathway key drivers of several responses in atopic inflammation. Dendritic cells (DCs) potent antigen-presenting crucial for the situ activation polarization T to induce appropriate primary immune responses. Under specific conditions DCs can produce IL-12 IL-23 promote Th1 Th17 cell activity, respectively, thus inducing distinct While IL-4 has been shown inhibit secretion by human DCs, less is known on effect this context. Hence we aimed investigate compare ability activated secrete IL-23. To end, assessed impact IL-4, alone or combination, expression release from monocyte-derived were with LPS IFN-γ. In study, found both partly IL-23, but not IL-12, DCs. Compared IL-13-treated treatment resulted stronger suppression secretion, suggesting dominant role over impairing despite sharing pathway. Treatment combination an additive inhibition compared alone. The inhibitory was reversed upon treatments specifically blocked and/or signaling. conclusion, modulation DC-mediated lower extent IL-13, may lead unwanted skewing block these cytokines.